Advances in Detection of Epigenetic Modification—5-Hydroxymethylcytosine
نویسندگان
چکیده
منابع مشابه
Loss of 5-Hydroxymethylcytosine Is an Epigenetic Hallmark of Melanoma
DNA methylation at the 5 position of cytosine (5-mC) is a key epigenetic mark that is critical for various biological and pathological processes. 5-mC can be converted to 5-hydroxymethylcytosine (5-hmC) by the ten-eleven translocation (TET) family of DNA hydroxylases. Here, we report that "loss of 5-hmC" is an epigenetic hallmark of melanoma, with diagnostic and prognostic implications. Genome-...
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The discovery of the Ten-Eleven-Translocation (TET) oxygenases that catalyze the hydroxylation of 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC) has triggered an avalanche of studies aiming to resolve the role of 5hmC in gene regulation if any. Hitherto, TET1 is reported to bind to CpG-island (CGI) and bivalent promoters in mouse embryonic stem cells, whereas binding at DNAseI hyperse...
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ژورنال
عنوان ژورنال: Acta Chimica Sinica
سال: 2021
ISSN: 0567-7351
DOI: 10.6023/a20120564